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The Folate Cycle
SLC19A1
Decreases activity
Intestinal transport of Zinc and folic acid: a mutual inhibitory effect. [PMID: 3946290 ]
New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development. [PMID: 19292860 ]
Increases activity
A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier. [PMID: 14760095 ]
Modulation of intestinal folate absorption by erythropoietin in vitro. [PMID: 24294939 ]
Mechanisms of membrane transport of folates into cells and across epithelia. [PMID: 21568705 ]
rs1051266
Kinetics
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. [PMID: 11705857 ]
Disease Associations
RFC-1 80G>A polymorphism in case-mother/control-mother dyads is associated with risk of nephroblastoma and neuroblastoma. [PMID: 25536437 ]
Association of reduced folate carrier-1 (RFC-1) polymorphisms with ischemic stroke and silent brain infarction. [PMID: 25659099 ]
The association between RFC1 G80A polymorphism and cancer susceptibility: Evidence from 33 studies. [PMID: 26819637 ]
FOLR2
Decreases activity
A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome. [PMID: 18355335 ]
MTHFD1
Function
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [ Homo sapiens (human) ] [PMID: Gene ]
Decreases activity
How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. [PMID: 18031821 ]
Increases activity
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. [PMID: 18767138 ]
Cofactor
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. [PMID: 18767138 ]
rs2236225
Kinetics
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. [PMID: 18767138 ]
Disease Associations
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. [PMID: 16236726 ]
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. [PMID: 12384833 ]
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. [PMID: 15633187 ]
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. [PMID: 16236726 ]
Nutrition in pregnancy: the argument for including a source of choline. [PMID: 23637565 ]
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. [PMID: 16236726 ]
MTHFR
Function
Folate: metabolism, genes, polymorphisms and the associated diseases. [PMID: 24091066 ]
Decreases activity
Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium. [PMID: 3818603 ]
Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues. [PMID: 7051769 ]
Inhibition of folate enzymes by sulfasalazine. [PMID: 22555 ]
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PMID: 25733650 ]
Metabolic features of the cell danger response. [PMID: 23981537 ]
Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation. [PMID: 15041476 ]
Increases activity
Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. [PMID: 22260268 ]
rs1801133
Kinetics
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. [PMID: 7647779 ]
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? [PMID: 9545395 ]
The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. [PMID: 10201405 ]
Disease Associations
Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis. [PMID: 25839940 ]
Association of the MTHFR C677T polymorphism and bone mineral density in postmenopausal women: a meta-analysis. [PMID: 23554658 ]
MTHFR-Ala222Val and male infertility: a study in Iranian men, an updated meta-analysis and an in silico-analysis. [PMID: 26380869 ]
Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial. [PMID: 23608654 ]
Methylenetetrahydrofolate reductase C677T polymorphism and congenital heart disease: a meta-analysis. [PMID: 21793799 ]
MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. [PMID: 19925624 ]
Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. [PMID: 17074966 ]
The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies. [PMID: 25486592 ]
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. [PMID: 10791559 ]
rs1801131
Kinetics
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? [PMID: 9545395 ]
Disease Associations
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? [PMID: 9545395 ]
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. [PMID: 17192785 ]
C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies. [PMID: 16691128 ]
The Methionine Cycle
MTRR
rs1801394
Kinetics
Methionine synthase reductase A66G polymorphism contributes to tumor susceptibility: evidence from 35 case-control studies. [PMID: 21547363 ]
Disease Associations
MTR and MTRR polymorphisms, dietary intake, and breast cancer risk. [PMID: 16537721 ]
Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant. [PMID: 15514263 ]
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. [PMID: 10444342 ]
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome. [PMID: 10930360 ]
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma. [PMID: 18483342 ]
Analysis of MTHFR and MTRR Gene Polymorphisms in Iranian Ventricular Septal Defect Subjects. [PMID: 23358257 ]
rs1532268
MAT1A
Decreases activity
Importance of a deficiency in S-adenosyl-L-methionine synthesis in the pathogenesis of liver injury. [PMID: 12418501 ]
Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. [PMID: 22260268 ]
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. [PMID: 9175157 ]
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. [PMID: 16054984 ]
Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection). [PMID: 24126418 ]
Increases activity
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. [PMID: 19158324 ]
Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. [PMID: 19293331 ]
rs72558181
Kinetics
Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. [PMID: 9042912 ]
Disease Associations
Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. [PMID: 9042912 ]
CBS
Decreases activity
Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels. [PMID: 17537983 ]
Hormonal regulation of cystathionine beta-synthase expression in liver. [PMID: 12198128 ]
Increases activity
Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. [PMID: 16100527 ]
1,25-dihydroxyvitamin D3 influences cellular homocysteine levels in murine preosteoblastic MC3T3-E1 cells by direct regulation of cystathionine β-synthase. [PMID: 21898591 ]
rs5742905
Kinetics
Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. [PMID: 16619244 ]
Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. [PMID: 17436311 ]
Molecular and biochemical approaches in the identification of heterozygotes for homocystinuria. [PMID: 8724113 ]
Disease Associations
rs4920037
rs28934891
Kinetics
Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient. [PMID: 8755636 ]
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. [PMID: 14722619 ]
Enzymatic diagnosis of homocystinuria by determination of cystathionine-ß-synthase activity in plasma using LC-MS/MS. [PMID: 25218699 ]
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase. [PMID: 12269827 ]
rs234706
Disease Associations
Association between SNPs in genes involved in folate metabolism and preterm birth risk. [PMID: 25730024 ]
Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits. [PMID: 23882023 ]
PP013. Single nucleotide polymorphisms of the maternal cystathionine-b-synthase gene are associated with preeclampsia (PE). [PMID: 26105871 ]
The Transsulfuration Pathway
SOD2
Decreases activity
Manganese superoxide dismutase in breast cancer: from molecular mechanisms of gene regulation to biological and clinical significance. [PMID: 25224035 ]
Selenium attenuates expression of MnSOD and uncoupling protein 2 in J774.2 macrophages: molecular mechanism for its cell-death and antiinflammatory activity. [PMID: 15650415 ]
Manganese superoxide dismutase and oxidative stress modulation. [PMID: 25858870 ]
Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. [PMID: 17079231 ]
Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. [PMID: 23963800 ]
Increases activity
Manganese superoxide dismutase and oxidative stress modulation. [PMID: 25858870 ]
Epigenetic regulation of human buccal mucosa mitochondrial superoxide dismutase gene expression by diet. [PMID: 18684339 ]
Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. [PMID: 23963800 ]
Ethanol treatment up-regulates the expression of mitochondrial manganese superoxide dismutase in rat liver. [PMID: 8024580 ]
Manganese superoxide dismutase in breast cancer: from molecular mechanisms of gene regulation to biological and clinical significance. [PMID: 25224035 ]
Sulforaphane decreases kidney injury after transplantation in rats: role of mitochondrial damage. [PMID: 24048440 ]
Moved Permanently [PMID: 21062349 ]
rs4880
Promoters
Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. [PMID: 23016763 ]
Kinetics
The manganese superoxide dismutase Ala16Val dimorphism modulates both mitochondrial import and mRNA stability. [PMID: 15864132 ]
Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. [PMID: 16538174 ]
The effect of superoxide anion and hydrogen peroxide imbalance on prostate cancer: an integrative in vivo and in vitro analysis. [PMID: 26468117 ]
Disease Associations
The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis. [PMID: 15591282 ]
Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort. [PMID: 18296681 ]
Gene variants encoding proteins involved in antioxidant defense system and the clinical expression of Wilson disease. [PMID: 24517502 ]
Association of the Ala16Val MnSOD gene polymorphism with plasma leptin levels and oxidative stress biomarkers in obese patients. [PMID: 25958349 ]
Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma. [PMID: 17290392 ]
Oxidative response gene polymorphisms and risk of adult brain tumors. [PMID: 18682580 ]
Superoxide Dismutase 2 Polymorphisms and Osteoporosis in Asian Indians: A Genetic Association Analysis. [PMID: 26336112 ]
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. [PMID: 19428448 ]
Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study. [PMID: 24146173 ]
Effect of 593C>T GPx1 SNP alone and in synergy with 47C>T SOD2 SNP on the outcome of critically ill patients. [PMID: 25497738 ]
Correlation between superoxide dismutase 1 and 2 polymorphisms and susceptibility to oral squamous cell carcinoma. [PMID: 24348785 ]
SOD3
Decreases activity
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. [PMID: 12126755 ]
Increases activity
Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. [PMID: 12126755 ]
rs1799895
Kinetics
10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain. [PMID: 8034674 ]
Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes. [PMID: 25855220 ]
Disease Associations
Genetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects. [PMID: 26844281 ]
Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. [PMID: 14662715 ]
A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. [PMID: 25085920 ]
GSTT1
Function
Structural basis of the suppressed catalytic activity of wild-type human glutathione transferase T1-1 compared to its W234R mutant. [PMID: 16298388 ]
Decreases activity
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. [PMID: 2222516 ]
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. [PMID: 11991805 ]
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. [PMID: 11058152 ]
Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis. [PMID: 9205086 ]
Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. [PMID: 17285300 ]
Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children. [PMID: 24217073 ]
Increases activity
Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. [PMID: 16083918 ]
Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. [PMID: 16971752 ]
The role of glutathione-S-transferase in anti-cancer drug resistance. [PMID: 14576844 ]
Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. [PMID: 19856314 ]
Modulation of gene methylation by genistein or lycopene in breast cancer cells. [PMID: 18181168 ]
Effects of nonsteroidal anti-inflammatory drugs on glutathione S-transferases of the rat digestive tract. [PMID: 9067546 ]
Concise review of the glutathione S-transferases and their significance to toxicology. [PMID: 10416260 ]
Cancer chemoprevention by targeting the epigenome. [PMID: 21158707 ]
Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. [PMID: 9288764 ]
The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. [PMID: 24237225 ]
Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. [PMID: 18676679 ]
Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells. [PMID: 20668305 ]
Spirulina improves antioxidant status by reducing oxidative stress in rabbits fed a high-cholesterol diet. [PMID: 20210608 ]
Sulfur amino acid restriction induces the pi class of glutathione S-transferase expression in primary rat hepatocytes. [PMID: 15867277 ]
Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. [PMID: 22931102 ]
GSTT1 deletion
Promoters
Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. [PMID: 12507929 ]
Systematic review: diet-gene interactions and the risk of colorectal cancer. [PMID: 23216531 ]
Misc References
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. [PMID: 11058152 ]
Kinetics
Glutathione S-transferase polymorphisms and their biological consequences. [PMID: 10971201 ]
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. [PMID: 8198545 ]
Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. [PMID: 16918316 ]
Disease Associations
Glutathione-S-transferase M1 and T1 null genotypes are associated with hypertension risk: a systematic review and meta-analysis of 12 studies. [PMID: 24788870 ]
GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against retinopathy. [PMID: 22377702 ]
Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population. [PMID: 18186040 ]
Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children. [PMID: 24217073 ]
Prospective Case-Control Study to Evaluate the Role of Glutathione S Transferases (GSTT1 and GSTM1) Gene Deletion in Breast Carcinoma and Its Prognostic Significance. [PMID: 27011512 ]
Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis. [PMID: 26350109 ]
Impact of null genotypes of GSTT1 and GSTM1 with uterine leiomyoma risk in Iranian population. [PMID: 26785830 ]
Null genotype of GSTT1 contributes to increased Parkinson's disease risk in Caucasians: evidence from a meta-analysis. [PMID: 25086621 ]
Association between GSTT-1 gene deletion and the susceptibility to oral squamous cell carcinoma in cigarette-smoking subjects. [PMID: 15878757 ]
Epidemiological factors related to GSTM1 and GSTT1 genes deletion in colon and rectum cancers: A case-control study. [PMID: 26406947 ]
Is there association between Glutathione S Transferases polymorphisms and cataract risk: a meta-analysis? [PMID: 26208492 ]
GST Theta null genotype is associated with an increased risk for ulcerative colitis: a case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease. [PMID: 25186055 ]
Genetic Polymorphism of GSTM1 and GSTT1 and Risk of Prostatic Carcinoma - a Meta-analysis of 7,281 Prostate Cancer Cases and 9,082 Healthy Controls. [PMID: 27268642 ]
Glutathione S transferase (GSTP 1, GSTM 1, and GSTT 1) gene polymorphisms in Egyptian patients with acute myeloid leukemia. [PMID: 26960454 ]
Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort. [PMID: 26959369 ]
Genetic polymorphisms by deletion in genes that encode for glutathione S-transferases are associated with nicotine dependence and tobacco use-related medical disorders. [PMID: 26812289 ]
Genetic polymorphisms by deletion in genes that encode for glutathione S-transferases are associated with nicotine dependence and tobacco use-related medical disorders. [PMID: 26812289 ]
Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology. [PMID: 16918316 ]
GSTP1
Decreases activity
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. [PMID: 2222516 ]
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. [PMID: 11991805 ]
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. [PMID: 11058152 ]
Polyunsaturated fatty acids inhibit the expression of the glucose-6-phosphate dehydrogenase gene in primary rat hepatocytes by a nuclear posttranscriptional mechanism. [PMID: 9788241 ]
Increases activity
Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. [PMID: 16083918 ]
Fermented wheat aleurone induces enzymes involved in detoxification of carcinogens and in antioxidative defence in human colon cells. [PMID: 20579402 ]
Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. [PMID: 19856314 ]
Modulation of gene methylation by genistein or lycopene in breast cancer cells. [PMID: 18181168 ]
Effects of nonsteroidal anti-inflammatory drugs on glutathione S-transferases of the rat digestive tract. [PMID: 9067546 ]
Concise review of the glutathione S-transferases and their significance to toxicology. [PMID: 10416260 ]
Cancer chemoprevention by targeting the epigenome. [PMID: 21158707 ]
Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. [PMID: 9288764 ]
The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. [PMID: 24237225 ]
Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. [PMID: 18676679 ]
Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells. [PMID: 20668305 ]
Sulfur amino acid restriction induces the pi class of glutathione S-transferase expression in primary rat hepatocytes. [PMID: 15867277 ]
rs1695
Kinetics
Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. [PMID: 9092542 ]
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. [PMID: 7925413 ]
GSTP1 mRNA expression in human circulating blood leukocytes is associated with GSTP1 genetic polymorphism. [PMID: 21669193 ]
Characterization of atrazine biotransformation by human and murine glutathione S-transferases. [PMID: 15115887 ]
Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity. [PMID: 22950985 ]
Disease Associations
Glutathione-S-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma. [PMID: 15612961 ]
Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. [PMID: 18988661 ]
GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. [PMID: 24465030 ]
Influence of genetic background and oxidative stress response on risk of mandibular osteoradionecrosis after radiotherapy of head and neck cancer. [PMID: 25352150 ]
Association between susceptibility to advanced pelvic organ prolapse and glutathione S-transferase P1 Ile105Val polymorphism. [PMID: 24582550 ]
Host genetic variations in glutathione-S-transferases, superoxide dismutases and catalase genes influence susceptibility to malaria infection in an Indian population. [PMID: 25573779 ]
Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis. [PMID: 26445852 ]
Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. [PMID: 25731870 ]
Association of glutathione S-transferase pi (GSTP1) Ile105Val polymorphism with the risk of skin cancer: a meta-analysis. [PMID: 26044055 ]
Association of glutathione S-transferase T1, M1, and P1 polymorphisms in the breast cancer risk: a meta-analysis. [PMID: 27274261 ]
GSTM1 and GSTP1 Genetic Polymorphisms and Their Associations With Acute Lymphoblastic Leukemia Susceptibility in a Jordanian Population. [PMID: 27299594 ]
Association between GSTP1 Ile105Val polymorphism and urinary system cancer risk: evidence from 51 studies. [PMID: 27366093 ]
Association between GSTP1 Ile105Val polymorphism and urinary system cancer risk: evidence from 51 studies. [PMID: 27366093 ]
rs1138272
Kinetics
Ecogenetics of mercury: from genetic polymorphisms and epigenetics to risk assessment and decision-making. [PMID: 24038486 ]
Disease Associations
GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. [PMID: 24465030 ]
The glutathione S-transferase P1 341C>T polymorphism and cancer risk: a meta-analysis of 28 case-control studies. [PMID: 23437223 ]
Polymorphisms in metabolism/antioxidant genes may mediate the effect of dietary intake on pancreatic cancer risk. [PMID: 24051964 ]
Ecogenetics of mercury: from genetic polymorphisms and epigenetics to risk assessment and decision-making. [PMID: 24038486 ]
Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review. [PMID: 18566111 ]
Genetic variability of DNA repair mechanisms and glutathione-S-transferase genes influences treatment outcome in osteosarcoma. [PMID: 25592234 ]
G6PD
Function
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. [PMID: 12829617 ]
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. [PMID: 22431005 ]
Decreases activity
Polyunsaturated fatty acids inhibit the expression of the glucose-6-phosphate dehydrogenase gene in primary rat hepatocytes by a nuclear posttranscriptional mechanism. [PMID: 9788241 ]
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. [PMID: 22431005 ]
Increases activity
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. [PMID: 12829617 ]
Rapid stimulation on the hexose monophosphate shunt in the isolated perfused rat heart: possible involvement of oxidized glutathione. [PMID: 7265260 ]
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. [PMID: 22431005 ]
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. [PMID: 12829617 ]
rs1050829
Kinetics
Molecular heterogeneity of glucose-6-phosphate dehydrogenase A-. [PMID: 2572288 ]
Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. [PMID: 19789650 ]
Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. [PMID: 19789650 ]
Disease Associations
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. [PMID: 12829617 ]
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. [PMID: 22431005 ]
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. [PMID: 12829617 ]
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. [PMID: 22431005 ]
rs1050828
Kinetics
A single mutation 202G>A in the human glucose-6-phosphate dehydrogenase gene (G6PD) can cause acute hemolysis by itself. [PMID: 11852882 ]
GPX1
Decreases activity
Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme. [PMID: 3619451 ]
How selenium has altered our understanding of the genetic code. [PMID: 11997494 ]
Increases activity
Properties and regulation of glutathione peroxidase. [PMID: 4319399 ]
Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. [PMID: 16971752 ]
Spirulina improves antioxidant status by reducing oxidative stress in rabbits fed a high-cholesterol diet. [PMID: 20210608 ]
Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. [PMID: 22931102 ]
Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer. [PMID: 17015256 ]
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. [PMID: 11507062 ]
α-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase. [PMID: 26365678 ]
Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. [PMID: 22931102 ]
rs1050450
Promoters
Supplementing culture and vitrification-warming media with l-ascorbic acid enhances survival rates and redox status of IVP porcine blastocysts via induction of GPX1 and SOD1 expression. [PMID: 24657197 ]
Kinetics
Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. [PMID: 16287877 ]
Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans. [PMID: 16538174 ]
Disease Associations
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density. [PMID: 18924182 ]
Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants. [PMID: 23906684 ]
Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. [PMID: 15331559 ]
Glutathione peroxidase 1 C593T polymorphism is associated with lobar intracerebral hemorrhage. [PMID: 18417962 ]
Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. [PMID: 18541588 ]
Association between the rs1050450 glutathione peroxidase-1 (CÂ >Â T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus. [PMID: 21185702 ]
Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. [PMID: 20578157 ]
Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. [PMID: 11103801 ]
Role of glutathione peroxidase 1 in breast cancer: loss of heterozygosity and allelic differences in the response to selenium. [PMID: 12810669 ]
Effect of 593C>T GPx1 SNP alone and in synergy with 47C>T SOD2 SNP on the outcome of critically ill patients. [PMID: 25497738 ]
The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. [PMID: 19428448 ]
XO
Decreases activity
Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. [PMID: 4359773 ]
Molecular basis of the biological function of molybdenum. Effect of tungsten on xanthine oxidase and sulfite oxidase in the rat. [PMID: 4359773 ]
SUOX
CAT
Increases activity
Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. [PMID: 16971752 ]
Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations. [PMID: 22119904 ]
Effects of beta-carotene on cell viability and antioxidant status of hepatocytes from chronically ethanol-fed rats. [PMID: 15333151 ]
The Biopterin Pathway
NOS3
Decreases activity
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes. [PMID: 8621775 ]
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. [PMID: 7685252 ]
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders. [PMID: 21172428 ]
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. [PMID: 12692136 ]
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. [PMID: 12482825 ]
A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression. [PMID: 15333612 ]
Increases activity
Arginine and endothelial and vascular health. [PMID: 15465805 ]
Nitric oxide synthases: regulation and function. [PMID: 21890489 ]
Morphology of smooth muscle cells in the rat thoracic duct. A scanning and transmission electron-microscope study. [PMID: 3345541 ]
Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity. [PMID: 20460711 ]
cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. [PMID: 15576651 ]
Estrogen modulation of endothelial nitric oxide synthase. [PMID: 12372846 ]
Cardiac energy metabolism and oxidative stress biomarkers in diabetic rat treated with resveratrol. [PMID: 25050809 ]
rs1800783
Disease Associations
Single-nucleotide polymorphisms in genes involved in placental function and unexplained stillbirth. [PMID: 23021696 ]
Genetic polymorphisms in nitric oxide synthase 3 gene and implications for kidney disease: a meta-analysis. [PMID: 20962522 ]
Genetic polymorphisms in nitric oxide synthase 3 gene and implications for kidney disease: a meta-analysis. [PMID: 20962522 ]
rs1800779
Disease Associations
Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake. [PMID: 16906563 ]
Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese population. [PMID: 18396156 ]
Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake. [PMID: 16906563 ]
SULT1A1
i6018900
Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation. [PMID: 16517757 ]
Kinetics
Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype. [PMID: 9345314 ]
Disease Associations
Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype. [PMID: 9345314 ]
Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia. [PMID: 25992585 ]
SULT1A1 Arg213His polymorphism is associated with bladder cancer risk: a meta-analysis. [PMID: 25194687 ]
Sulfotransferase SULT1A1 Arg213His polymorphism with cancer risk: a meta-analysis of 53 case-control studies. [PMID: 25225888 ]
Decreases activity
3'-Phosphoadenosine 5'-phosphosulfate allosterically regulates sulfotransferase turnover. [PMID: 25314023 ]
Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. [PMID: 17876860 ]
Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature. [PMID: 15487807 ]
Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues. [PMID: 12745871 ]
Inhibition of rat liver sulfotransferases SULT1A1 and SULT2A1 and glucuronosyltransferase by dietary flavonoids. [PMID: 14742143 ]
Sulfation of dietary flavonoids by human sulfotransferases. [PMID: 19350454 ]
Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. [PMID: 24089703 ]
Increases activity
Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. [PMID: 9034160 ]
3'-Phosphoadenosine 5'-phosphosulfate allosterically regulates sulfotransferase turnover. [PMID: 25314023 ]
Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine. [PMID: 22390687 ]
COMT
Decreases activity
The catechol-O-methyltransferase gene: its regulation and polymorphisms. [PMID: 21095457 ]
Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition. [PMID: 12711835 ]
O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. [PMID: 20606002 ]
Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. [PMID: 10385681 ]
The catechol-O-methyltransferase gene: its regulation and polymorphisms. [PMID: 21095457 ]
O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. [PMID: 20606002 ]
Increases activity
COMT-by-sex interaction effect on psychosis proneness. [PMID: 25722988 ]
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. [PMID: 9707588 ]
The catechol-O-methyltransferase gene: its regulation and polymorphisms. [PMID: 21095457 ]
rs4680
Kinetics
Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes. [PMID: 14966473 ]
Genetic basis for individual variations in pain perception and the development of a chronic pain condition. [PMID: 15537663 ]
Disease Associations
Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis. [PMID: 22722321 ]
The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. [PMID: 22707271 ]
Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. [PMID: 17325717 ]
Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy. [PMID: 25963335 ]
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis. [PMID: 24390993 ]
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis. [PMID: 20488458 ]
Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study. [PMID: 22612913 ]
Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. [PMID: 26390831 ]
A Genetic Variant (COMT) Coding Dopaminergic Activity Predicts Personality Traits in Healthy Elderly. [PMID: 25960587 ]
Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese. [PMID: 22790479 ]
Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk. [PMID: 18064318 ]
COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. [PMID: 18324659 ]
rs4633
Kinetics
COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. [PMID: 18324659 ]
Disease Associations
Common variants of catechol-O-methyltransferase influence patient-controlled analgesia usage and postoperative pain in patients undergoing total hysterectomy. [PMID: 25963335 ]
Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese. [PMID: 22790479 ]
Genetic contribution of catechol-O-methyltransferase variants in treatment outcome of low back pain: a prospective genetic association study. [PMID: 22612913 ]
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analysis. [PMID: 20488458 ]
MAOA
Decreases activity
Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review. [PMID: 26429556 ]
Transcriptional regulation and multiple functions of MAO genes. [PMID: 21359973 ]
Brain monoamine oxidase A inhibition in cigarette smokers. [PMID: 8943061 ]
8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. [PMID: 12130655 ]
Berberine: a potential multipotent natural product to combat Alzheimer's disease. [PMID: 21829148 ]
Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. [PMID: 26499200 ]
Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. [PMID: 23009399 ]
The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey. [PMID: 824661 ]
Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. [PMID: 9698044 ]
Increases activity
Effect of ascorbic acid on the human electroencephalogram. [PMID: 1099176 ]
Influence of estradiol-17 beta and progesterone on catechol-O-methyltransferase and monoamine oxidase activities in uterine artery and myometrium of ovariectomized pigs. [PMID: 8055052 ]
Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. [PMID: 23009399 ]
Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy. [PMID: 26122707 ]
Upregulation of serotonin transporter by alcohol in human dendritic cells: possible implication in neuroimmune deregulation. [PMID: 19572987 ]
Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages. [PMID: 26052543 ]
Activation of monoamine oxidase and inhibition of aldehyde dehydrogenase by reserpine. [PMID: 5680364 ]
rs6323
Kinetics
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. [PMID: 19593178 ]
Monoamine oxidase a gene is associated with borderline personality disorder. [PMID: 17417058 ]
The placebo effect: From concepts to genes. [PMID: 26272535 ]
Disease Associations
Sexual dimorphic effect in the genetic association of monoamine oxidase A (MAOA) markers with autism spectrum disorder. [PMID: 24291416 ]
rs1137070
Kinetics
A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. [PMID: 20691428 ]
Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines. [PMID: 19915868 ]
Disease Associations
MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders. [PMID: 26227907 ]
The Altered Brain Activation of Phonological Working Memory, Dual Tasking, and Distraction Among Participants With Adult ADHD and the Effect of the MAOA Polymorphism. [PMID: 25777072 ]
Functional polymorphisms of the MAO gene with Parkinson disease susceptibility: a meta-analysis. [PMID: 25066260 ]
Monoamine oxidase A gene polymorphisms and enzyme activity associated with risk of gout in Taiwan aborigines. [PMID: 19915868 ]
MAOB
Decreases activity
Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells. [PMID: 22968599 ]
Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition. [PMID: 9549600 ]
Berberine: a potential multipotent natural product to combat Alzheimer's disease. [PMID: 21829148 ]
Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling. [PMID: 26499200 ]
Evaluation of the inhibitory effects of quercetin-related flavonoids and tea catechins on the monoamine oxidase-A reaction in mouse brain mitochondria. [PMID: 23009399 ]
Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. [PMID: 9698044 ]
The effects of testosterone on plasma and platelet monoamine oxidase (MAO) an plasma dopamine-beta-hydroxylase (DBH) activities in the male rhesus monkey. [PMID: 824661 ]
High throughput screening to identify natural human monoamine oxidase B inhibitors. [PMID: 22887993 ]
Protective effect of green tea (-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains. [PMID: 20472400 ]
Increases activity
Effect of ascorbic acid on the human electroencephalogram. [PMID: 1099176 ]
Influence of estradiol-17 beta and progesterone on catechol-O-methyltransferase and monoamine oxidase activities in uterine artery and myometrium of ovariectomized pigs. [PMID: 8055052 ]
The effect of age on the activity and molecular properties of human brain monoamine oxidase. [PMID: 7441234 ]
Hydrogen peroxide enhances the activity of monoamine oxidase type-B but not of type-A: a pilot study. [PMID: 3097261 ]
Activation of monoamine oxidase and inhibition of aldehyde dehydrogenase by reserpine. [PMID: 5680364 ]
rs1799836
Kinetics
Association analysis of the functional MAOA gene promoter and MAOB gene intron 13 polymorphisms in tension type headache patients. [PMID: 25618115 ]
An abnormal mRNA produced by a novel PMP22 splice site mutation associated with HNPP. [PMID: 16199442 ]
The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis. [PMID: 24658549 ]
Investigation of the functional effect of monoamine oxidase polymorphisms in human brain. [PMID: 11810289 ]
Disease Associations
Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese. [PMID: 21978760 ]
Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. [PMID: 19657584 ]
Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. [PMID: 21971001 ]
Association of a monoamine oxidase B allele with Parkinson's disease. [PMID: 8489207 ]
Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population. [PMID: 18832861 ]
Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. [PMID: 21781348 ]
A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. [PMID: 26000819 ]
The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis. [PMID: 24658549 ]
The Histamine Pathway
AOC1
Decreases activity
Structure and inhibition of human diamine oxidase. [PMID: 19764817 ]
Increases activity
Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. [PMID: 20668027 ]
rs10156191
Kinetics
Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity. [PMID: 17700358 ]
Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. [PMID: 25612138 ]
Disease Associations
Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. [PMID: 25612138 ]
The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs. [PMID: 23152756 ]
Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. [PMID: 21488903 ]
NAT2
Disease Associations
Association Between N-acetyltransferase 2 Polymorphism and Bladder Cancer Risk: Results From Studies of the Past Decade and a Meta-Analysis. [PMID: 26585839 ]
NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis. [PMID: 20180012 ]
Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis. [PMID: 18187392 ]
Susceptibility of N-acetyltransferase 2 slow acetylators to antituberculosis drug-induced liver injury: a meta-analysis. [PMID: 26616266 ]
Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe. [PMID: 18199719 ]
Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans. [PMID: 26683305 ]
Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. [PMID: 11751443 ]
Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. [PMID: 7881341 ]
Meat consumption patterns and preparation, genetic variants of metabolic enzymes, and their association with rectal cancer in men and women. [PMID: 15051825 ]
Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo. [PMID: 25604583 ]
Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer. [PMID: 12584178 ]
Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies. [PMID: 25342387 ]
N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. [PMID: 11927838 ]
NAT2 slow acetylation genotypes contribute to asthma risk among Caucasians: evidence from 946 cases and 1,091 controls. [PMID: 24442317 ]
Association between the N-acetylation genetic polymorphism and bronchial asthma. [PMID: 12492617 ]
A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. [PMID: 20739907 ]
Bonus SNPs
HFE
BCO1
Misc References
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. [PMID: 19185284 ]
Single nucleotide polymorphisms upstream from the β-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers. [PMID: 22113863 ]
beta-Carotene conversion products and their effects on adipose tissue. [PMID: 19557453 ]
NQO1
Misc References
Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1. [PMID: 11160862 ]
A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. [PMID: 10393963 ]
FUT2
PEMT
rs7946
Misc References
Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). [PMID: 16051693 ]
An overview of the genetics, mechanisms and management of NAFLD and ALD. [PMID: 26634687 ]
Genetic modifiers of non-alcoholic fatty liver disease progression. [PMID: 21840395 ]
Common genetic polymorphisms affect the human requirement for the nutrient choline. [PMID: 16816108 ]
Nutrition in pregnancy: the argument for including a source of choline. [PMID: 23637565 ]
FADS1
FADS2
Misc References
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. [PMID: 21829377 ]
Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study. [PMID: 23861364 ]
TNF alpha
Misc References
Association between the tumour necrosis factor-α-308G/A polymorphism and chronic obstructive pulmonary disease: an update. [PMID: 20946339 ]
A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis. [PMID: 22043116 ]
Associations between tumor necrosis factor alpha gene -238 G/A and -308 G/A polymorphisms and the risk of pneumoconiosis: update of a meta-analysis. [PMID: 23919499 ]
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis. [PMID: 24142527 ]
Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA. [PMID: 24160187 ]
Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis. [PMID: 24936650 ]
Association between TNF-α rs1799724 and rs1800629 polymorphisms and the risk of Crohn's disease. [PMID: 26634549 ]
Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis. [PMID: 26837816 ]
Tumor necrosis factor-308 polymorphism with the risk and prognosis of non-Hodgkin lymphomas: a meta-analysis study. [PMID: 27051301 ]
LRRK2
VDR
Misc References
Vitamin D Receptor Genetic Polymorphisms and Prostate Cancer Risk: A Meta-analysis of 36 Published Studies. [PMID: 19684888 ]
Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies. [PMID: 23134477 ]
Genetics and biology of vitamin D receptor polymorphisms. [PMID: 15315818 ]
The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. [PMID: 10707958 ]